Osteopoikilosis is an asymptomatic osteosclerotic dysplasia of unknown pathogenesis seen in both men and women.
Clinical manifestations usually are absent or mild. Roentgenographic findings are diagnostic. Numerous small, well-defined, homogeneous circular or ovoid foci of increased radiodensity are clustered in periarticular osseous regions. A symmetric distribution is observed, with a predilection for the epiphyses and metaphyses of long tubular bones, carpus, tarsus, pelvis, and scapulae; involvement of the ribs, clavicles, spine, and skull is rare and, when present, is less marked. Radionuclide examination with bone-seeking radiopharmaceutical agents usually reveals no evidence of increased activity about the skeletal lesions. The microscopic features of the lesion are identical to those encountered in bone islands.
Clinical manifestations usually are absent or mild. Roentgenographic findings are diagnostic. Numerous small, well-defined, homogeneous circular or ovoid foci of increased radiodensity are clustered in periarticular osseous regions. A symmetric distribution is observed, with a predilection for the epiphyses and metaphyses of long tubular bones, carpus, tarsus, pelvis, and scapulae; involvement of the ribs, clavicles, spine, and skull is rare and, when present, is less marked. Radionuclide examination with bone-seeking radiopharmaceutical agents usually reveals no evidence of increased activity about the skeletal lesions. The microscopic features of the lesion are identical to those encountered in bone islands.